ATP12, ATP synthase F1-assembly protein (IPR011419)

Short name: ATP12_ATP_synth-F1-assembly

Overlapping homologous superfamilies

Family relationships



This entry represents a group proteins from eukaryotes and bacteria that may have chaperone activity and be involved in F1 ATPase complex assembly. The eukaryotic proteins include yeast ATP12 [PMID: 1826907] and mammalian homologue ATPAF2 (ATP synthase mitochondrial F1 complex assembly factor 2) [PMID: 12965202], which are required for assembly of the mitochondrial F1-ATPase.

Mitochondrial F1-ATPase is an oligomeric enzyme composed of five distinct subunit polypeptides. The alpha and beta subunits make up the bulk of protein mass of F1. In Saccharomyces cerevisiae both subunits are synthesised as precursors with N-terminal targeting signals that are removed upon translocation of the proteins to the matrix compartment [PMID: 1826907].

GO terms

Biological Process

GO:0043461 proton-transporting ATP synthase complex assembly

Molecular Function

No terms assigned in this category.

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.