AP180 N-terminal homology (ANTH) domain (IPR011417)

Short name: ANTH_dom

Overlapping homologous superfamilies


Domain relationships



The AP180 N-terminal homology (ANTH) domain is a membrane binding domain found in endocytotic accessory proteins, such as AP180. AP180 has been implicated in the formation of clathrin-coated pits. The ANTH domain is involved in phosphatidylinositol 4,5-bisphosphate (also known as PIP2) binding. The ANTH domain containing proteins appear to be universal elements in nucleation of clathrin coats [PMID: 12740367, PMID: 12742163].

GO terms

Biological Process

No terms assigned in this category.

Molecular Function

GO:0005543 phospholipid binding

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.