Family

Sphingolipid delta4-desaturase (IPR011388)

Short name: DES1/DES2

Family relationships

None.

Description

This group represents sphingolipid delta-4 desaturase (DEGS), an integral membrane protein required for sphingosine biosynthesis. It converts D-erythro-sphinganine to D-erythro-sphingosine (E-sphing-4-enine) [PMID: 11937514]. Delta4-desaturated sphingolipids provide an early signal that triggers the entry into both meiotic and spermatid differentiation pathways during Drosophila spermatogenesis [PMID: 11937514].

GO terms

Biological Process

GO:0030148 sphingolipid biosynthetic process

Molecular Function

GO:0042284 sphingolipid delta-4 desaturase activity

Cellular Component

GO:0016021 integral component of membrane

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
CDD
  • cd03508 (Delta4-sphingolipid-FADS-like)
PIRSF