17beta-dehydrogenase (IPR011348)

Short name: 17beta_DH

Overlapping homologous superfamilies

Family relationships


This entry represents 17beta-hydroxysteroid dehydrogenases (17B-HSDs), a group of enzymes which catalyse the last step in the biosynthesis of all androgens and estrogens -the reversible NAD(P)-linked transfer of a hydride to and from the 17-position of steroid molecules [PMID: 8943783]. A total of six isozymes have been identified which vary in substrate specificity, tissue specificity and preferred direction of the reaction.

The most intensively studied enzyme in this entry is human estrogenic 17beta-hydroxysteroid dehydrogenase (P14061) which is responsible for the last step in the synthesis of all estrogens. As active estrogens stimulate the proliferation of breast cancer cells, this enzyme is a potential target for drugs to treat breast cancer [PMID: 9927655]. It is a membrane-associated homodimer which posseses the Tyr-X-X-X-Lys motif typical of short-chain dehydrogenases and forms a typical Rossman fold [PMID: 7663947].

GO terms

Biological Process

GO:0006703 estrogen biosynthetic process
GO:0055114 oxidation-reduction process

Molecular Function

GO:0004303 estradiol 17-beta-dehydrogenase activity

Cellular Component

GO:0005737 cytoplasm

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.