Homologous Superfamily

Salt-mediated killer toxin, alpha subunit (IPR011328)

Short name: SMK_a

Overlapping entries


The killer toxin SMK (salt-mediated killer) from the halotolerant yeast Pichia farinosa acts to kill sensitive strains of yeast. SMK exhibits maximum activity under conditions of acidic pH and high salt concentration. It is composed of two distinct subunits, alpha and beta, which tightly interact with each other under acidic conditions, jointly folding into an ellipsoidal single domain structure belonging to the alpha/beta-sandwich family. SMK assumes a similar folding topology to the fungal killer toxin KP4, forming two left-handed split beta/alpha/beta motifs, which is rarely found in other toxins; hence, these toxins may be evolutionarily or functionally related [PMID: 9016714]. SMK appears to function by associating with the membranes of sensitive cells [PMID: 11748724].

This superfamily represents the beta subunit of SMK.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.