Pathways & interactions
Mss4/translationally controlled tumour-associated TCTP (IPR011323)
Short name: Mss4/transl-control_tumour
- Mss4 (IPR007515)
- Mss4-like superfamily (IPR011057)
- Translationally controlled tumour protein (IPR018105)
- Translationally controlled tumour protein (TCTP) domain (IPR034737)
This superfamily represents a structural domain with a complex fold consisting of several coiled beta-sheets. This domain exists as a duplication, consisting of a tandem repeat of two similar structural motifs. This entry represents copies of this structural motif in the following protein families:
- Mss4, which contains a zinc-binding site.
- Translationally controlled tumour-associated protein TCTP, which contains an insertion of an alpha-helix hairpin, and which lacks a zinc-binding site.
Mss4 is a conserved accessory factor for Rab GTPases, which function as ubiquitous regulators of intracellular membrane trafficking [PMID: 11258916]. Mss4 acts to promote nucleotide release from exocytic but not endocytic Rab GTPases. Mss4 has a complex fold made of several coiled beta-sheets, and consists of a duplication of tandem repeats of two similar structural motifs. It contains a zinc-binding site.
Other proteins that show structural similarity to Mss4 include the translationally controlled tumour-associated proteins TCTPs, which contain an insertion of an alpha helical hairpin, and lack the zinc-binding site. TCTPs are a highly conserved and abundantly expressed family of eukaryotic proteins that are implicated in both cell growth and the human acute allergic response [PMID: 11473261].
- G3DSA:188.8.131.52 (G3DSA:184.108.40.206)