3-oxoacyl-(acyl-carrier-protein) reductase (IPR011284)

Short name: 3oxo_ACP_reduc

Overlapping homologous superfamilies

Family relationships


This entry represents 3-oxoacyl-[ACP] reductase, also called 3-ketoacyl-acyl carrier protein reductase, an enzyme of fatty acid biosynthesis found in many plant and bacterial species. This enzyme is involved in type II fatty acid biosynthesis, where the individual metabolic transformations are carried out by different enzymes rather than by a single enzyme as occurs in type I fatty acid biosynthesis [PMID: 11544358]. This family includes Sinorhizobium meliloti NodG, which has been shown to be a 3-oxoacyl-ACP reductase and can play a role in fatty acid synthesis [PMID: 26975437].

Structural studies show that the enzyme is a tetramer which forms a typical Rossman fold [PMID: 11669613, PMID: 16225460]. Unlike other members of the short-chain dehydrogenase/reductase superfamily, the enzyme undergoes a marked conformational change upon binding of the NADP(H)cofactor. This conformational change aligns the side chains of the catalytic triad at the active site in an active conformation and increases the affinity of the enzyme for its substrate.

GO terms

Biological Process

GO:0006633 fatty acid biosynthetic process
GO:0055114 oxidation-reduction process

Molecular Function

GO:0004316 3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity
GO:0051287 NAD binding

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.