2-methylcitrate synthase/citrate synthase type I (IPR011278)

Short name: 2-MeCitrate/Citrate_synth_II

Family relationships


Members of this family are dimeric enzymes with activity as 2-methylcitrate synthase, citrate synthase, or both. Many Gram-negative species have a hexameric citrate synthase, termed citrate synthase I. Members of this family appear as a second citrate synthase isozyme, but typically are associated with propionate metabolism and synthesise 2-methylcitrate from propionyl-CoA; citrate synthase activity may be incidental [PMID: 9579066]. A number of species, including Thermoplasma acidophilum, Pyrococcus furiosus, and the Antarctic bacterium DS2-3R have a bifunctional member of this family as the only citrate synthase isozyme.

GO terms

Biological Process

No terms assigned in this category.

Molecular Function

GO:0046912 transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer

Cellular Component

GO:0005737 cytoplasm

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.