Malate dehydrogenase, NAD-dependent, cytosolic (IPR011274)

Short name: Malate_DH_NAD-dep_euk

Overlapping homologous superfamilies

Family relationships


Malate dehydrogenase (MDH) is one of the key enzymes in the citric acid cycle, facilitating both the conversion of malate to oxaloacetate and replenishing levels of oxalacetate by reductive carboxylation of pyruvate [PMID: 11389141]. There are several isoforms of MDH, differing in their subcellular localization and their specificity for the cofactor NAD or NADP [PMID: 9834842]. Members of this family are eukaryotic NAD-dependent MDHs localized to the cytoplasm and cytosol.

The enzyme from pig has been studied by X-ray crystallography [PMID: 2775751].

GO terms

Biological Process

GO:0006108 malate metabolic process
GO:0055114 oxidation-reduction process

Molecular Function

GO:0030060 L-malate dehydrogenase activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
  • cd01336 (MDH_cytoplasmic_cytosolic)