Purine nucleoside phosphorylase I, inosine/guanosine-specific (IPR011270)

Short name: Pur_Nuc_Pase_Ino/Guo-sp

Overlapping homologous superfamilies

Family relationships


This entry represents a family of bacterial and metazoan purine phosphorylases acting primarily on inosine and guanosine and not acting on adenosine. PNP-I refers to the nomenclature from Bacillus stearothermophilus (Geobacillus stearothermophilus) [PMID: 9058965] where PHP-II refers to the nucleotidase acting on adenosine as the primary substrate. The bacterial enzymes (PUNA) are typified by the Bacillus PupG protein [PMID: 10537218] which is involved in the metabolism of nucleosides as a carbon source. Several metazoan enzymes (PNPH) are well characterised including the human [PMID: 2104852] and bovine [PMID: 9020983] enzymes which have been crystallised.

GO terms

Biological Process

GO:0006139 nucleobase-containing compound metabolic process

Molecular Function

GO:0004731 purine-nucleoside phosphorylase activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.