Homologous Superfamily

Fibrogen-binding domain 1 (IPR011252)

Short name: Fibrogen-bd_dom1

Overlapping entries


This superfamily represents fibrinogen-binding domain 1. In proteins such as fibrinogen-binding adhesion SdrG and clumping factor A, there are two fibrinogen-binding domains with similar core beta-sandwich topologies, but with different modulations in their structure. This entry represents the first domain, while IPR011266 represents the second domain.

Gram-positive pathogens, such as Staphylococci, Streptococci, and Enterococci, contain multiple cell wall-anchored proteins. Some of these proteins act as adhesins and mediate bacterial attachment to host tissues through lock-and-interactions with host ligands, such as fibrinogen, a glycoprotein found in blood plasma that plays a key role in haemostasis and coagulation. For pathogenic bacteria that do not invade host cells, extracellular matrix proteins are preferred targets for bacterial adhesion; adhesins mediating these interactions have been termed MSCRAMMs (microbial surface components recognizing adhesive matrix molecules). A common binding domain organisation found within MSCRAMMs suggests a common ancestry. Both fibrinogen-binding adhesion SdrG and clumping factor A are MSCRAMMs. Fibrinogen-binding adhesion SdrG is a cell wall-anchored adhesion found in the pathogen Mycobacterium farcinogenes that binds to the B-beta chain of human fibrinogen [PMID: 14567919], while clumping factor A performs a similar function in Staphylococcus aureus by binding the gamma chain of fibrinogen [PMID: 12485987].

GO terms

Biological Process

GO:0007155 cell adhesion

Molecular Function

No terms assigned in this category.

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.