Bifunctional acetylglutamate kinase/N-acetyl-gamma-glutamyl-phosphate reductase (IPR011241)

Short name: NAGK/NAGSA

Overlapping homologous superfamilies


Family relationships



This group represents a bifunctional acetylglutamate kinase (EC: reductase (EC:, which is found in fungi. It contains an N-terminal acetylglutamate kinase (also known as N-acetyl-L-glutamate kinase, NAGK) domain and a C-terminal N-acetyl-gamma-glutamyl-phosphate reductase (NAGSA) domain [PMID: 1313366].

The budding yeast member, Arg5,6, is expressed as a precursor that is then maturated in the mitochondria into acetylglutamate kinase and acetylglutamyl-phosphate reductase. It is involved in the arginine biosynthesis pathway, catalyzing the second and third steps in the pathway [PMID: 11553611].

GO terms

Biological Process

GO:0006526 arginine biosynthetic process

Molecular Function

GO:0003942 N-acetyl-gamma-glutamyl-phosphate reductase activity
GO:0003991 acetylglutamate kinase activity

Cellular Component

GO:0005739 mitochondrion

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.