Family

Serine/threonine protein phosphatase 5 (IPR011236)

Short name: Ser/Thr_PPase_5

Family relationships

None.

Description

These eukaryotic serine/threonine phosphoprotein phosphatases, first described from human (PP5) and Saccharomyces cerevisiae (PPT1), are distinguished from related protein phosphatases by an N-terminal region of about 200 residues that contains three tandem tetratricopeptide repeats (TPR) [PMID: 7925273]. Structurally, TPR repeats form a helical scaffold of antiparallel alpha-helices with an amphipathic groove that mediates protein-protein interactions [PMID: 9482716]. The TPR domains contribute to regulation of PP5 activity, which is normally low but stimulated by interaction with lipid [PMID: 11523989], and to interaction with other proteins [PMID: 11504734].

GO terms

Biological Process

GO:0006470 protein dephosphorylation

Molecular Function

GO:0004721 phosphoprotein phosphatase activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
PANTHER