Family

Isopentenyl-diphosphate delta-isomerase, FMN-dependent (IPR011179)

Short name: IPdP_isomerase

Overlapping homologous superfamilies

Family relationships

None.

Description

This entry represents the bacterial and archaeal isopentenyl-diphosphate delta-isomerase (IPP isomerase). IPP isomerase catalyses the interconversion of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), and is a key enzyme in the biosynthesis of isoprenoids via the mevalonate pathway. The bacterial and archaeal IPP isomerase (type 2 enzyme) differs from that found in eukaryotes (type 1 enzyme), and requires NADPH, magnesium, and FMN for activity [PMID: 15009187, PMID: 12798687].

GO terms

Biological Process

GO:0008299 isoprenoid biosynthetic process

Molecular Function

GO:0010181 FMN binding
GO:0004452 isopentenyl-diphosphate delta-isomerase activity

Cellular Component

GO:0005737 cytoplasm

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
TIGRFAMs
PIRSF
HAMAP
CDD
PANTHER