Glia maturation factor (IPR011171)

Short name: GMF

Overlapping homologous superfamilies

Family relationships


This entry represents glia maturation factor beta and gamma (GMFB/GMFG), Aim7 from budding yeasts and Gmf1 from fission yeasts. GMF family proteins do not interact with actin, but instead bind to Arp2/3 complex. They sever actin-Arp2/3 complex branch junctions by a cofilin-like mechanism [PMID: 23727094, PMID: 23897816].

Human GMFB was initially identified as a growth and differentiation factor acting on neurons as well as glia in the vertebrate brain. GMFB is produced predominantly in the thymus, and may have roles in both intracellular signal transduction and T cell development [PMID: 12697657].

Fission yeast Gmf1 is an actin depolymerising factor involved in the control of the disassembly of actin patches [PMID: 20517925]. Aim7 binds Arp2/3 complex to stimulate filament debranching and inhibit actin nucleation [PMID: 20517925].

GO terms

Biological Process

GO:0034316 negative regulation of Arp2/3 complex-mediated actin nucleation

Molecular Function

GO:0071933 Arp2/3 complex binding

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.