Domain

Holliday junction DNA helicase RuvA, C-terminal (IPR011114)

Short name: RuvA_C

Domain relationships

None.

Description

In prokaryotes, RuvA, RuvB, and RuvC process the universal DNA intermediate of homologous recombination, termed Holliday junction. The tetrameric DNA helicase RuvA specifically binds to the Holliday junction and facilitates the isomerization of the junction from the stacked folded configuration to the square-planar structure [PMID: 12408833]. In the RuvA tetramer, each subunit consists of three domains, I, II and III, where I and II form the major core that is responsible for Holliday junction binding and base pair rearrangements of Holliday junction executed at the crossover point, whereas domain III regulates branch migration through direct contact with RuvB.

The domain represents the C-terminal domain III of RuvA. This domain plays a significant role in the ATP-dependent branch migration of the hetero-duplex through direct contact with RuvB [PMID: 10890893]. Within the Holliday junction, this domain makes no interaction with the DNA.

GO terms

Biological Process

GO:0006310 DNA recombination
GO:0006281 DNA repair

Molecular Function

GO:0005524 ATP binding
GO:0009378 four-way junction helicase activity

Cellular Component

GO:0009379 Holliday junction helicase complex

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
CDD
Pfam
SUPERFAMILY