Domain

HPr kinase/phosphorylase, C-terminal (IPR011104)

Short name: Hpr_kin/Pase_C

Domain relationships

None.

Description

This entry represents the C-terminal kinase domain of Hpr Serine/threonine kinase PtsK. This kinase is the sensor in a multicomponent phosphorelay system in control of carbon catabolic repression in bacteria [PMID: 9570401]. This kinase in unusual in that it recognises the tertiary structure of its target and is a member of a novel family unrelated to any previously described protein phosphorylating enzymes [PMID: 9570401]. X-ray analysis of the full-length crystalline enzyme from Staphylococcus xylosus at a resolution of 1.95 A shows the enzyme to consist of two clearly separated domains that are assembled in a hexameric structure resembling a three-bladed propeller [PMID: 11904409].

GO terms

Biological Process

GO:0000160 phosphorelay signal transduction system
GO:0006109 regulation of carbohydrate metabolic process

Molecular Function

GO:0005524 ATP binding
GO:0000155 phosphorelay sensor kinase activity
GO:0004672 protein kinase activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
Pfam