HR1 rho-binding domain (IPR011072)

Short name: HR1_rho-bd

Overlapping homologous superfamilies


Domain relationships


HR1 was first described as a three times repeated homology region of the N-terminal non-catalytic part of protein kinase PRK1(PKN) [PMID: 7851406]. The first two of these repeats were later shown to bind the small G protein rho [PMID: 8647255, PMID: 9446575] known to activate PKN in its GTP-bound form. Similar rho-binding domains also occur in a number of other protein kinases and in the rho-binding proteins rhophilin and rhotekin. Recently, the structure of the N-terminal HR1 repeat complexed with RhoA has been determined by X-ray crystallography [PMID: 10619026]. It forms an antiparallel coiled-coil fold termed an ACC finger.

GO terms

Biological Process

GO:0007165 signal transduction

Molecular Function

No terms assigned in this category.

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.