Homologous Superfamily

Polysaccharide lyase family 8-like, C-terminal (IPR011071)

Short name: Lyase_8-like_C

Overlapping entries


Proteins containing this C-terminal domain consist of a group of secreted bacterial lyase enzymes capable of acting on a variety of substrates. One such enzyme is hyaluronate lyase, a Streptococcal surface enzyme that degrades hyaluronan and chondroitin, thereby helping to spread the bacteria throughout host tissues [PMID: 14523022]. Hyaluronate lyase (EC: is a four-domain enzyme containing an N-terminal carbohydrate-binding domain, a spacer domain, a catalytic domain, and a C-terminal domain that modulates access to the catalytic cleft of the enzyme. The C-terminal domain has a beta sandwich fold consisting of 10 strands in two sheets. Other bacterial enzymes that display this structure include the C-terminal domain of chondroitin AC lyase (EC: [PMID: 10329169], the C-terminal domain of chondroitin ABC lyase (EC: [PMID: 12706721], and the C-terminal domain of xanthan lyase (EC: [PMID: 12475987]. This entry represents the C-terminal domain of hyaluronate lyase, chondroitin AC lyase, chondroitin ABC lyase and xanthan lyase.

GO terms

Biological Process

GO:0005975 carbohydrate metabolic process

Molecular Function

No terms assigned in this category.

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.