Homologous Superfamily

Hirudin/antistatin (IPR011061)

Short name: Hirudin/antistatin

Overlapping entries


Leeches, such as Hirudo medicinalis (Medicinal leech), produce a variety of antihaemostatic proteins that act as proteinase inhibitors. These inhibitors are used to aid the leech in feeding upon its host by blocking blood coagulation [PMID: 11563948, PMID: 11257492]. Examples of these proteins include hirustasin (inhibitor of tissue kallikrein, trypsin, alpha-chymotrypsin, and granulocyte cathepsin G) [PMID: 10368273], bdellastasin (inhibitor of trypsin, plasmin, and acrosin) [PMID: 10512718], factor Xa inhibitor antistasin (inhibitor of blood coagulation factor Xa) [PMID: 9311976], hirudin (thrombin inhibitor), decorsin (inhibitor of platelet aggregation) [PMID: 8607116] and haemadin (thrombin inhibitor) [PMID: 11851400].

GO terms

Biological Process

No terms assigned in this category.

Molecular Function

GO:0004857 enzyme inhibitor activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.