Homologous Superfamily

Duplicated hybrid motif (IPR011055)

Short name: Dup_hybrid_motif

Description

The duplicated hybrid motif is a structural motif that is found in certain glucose-permease-like enzymes, and consists of a half-barrel beta-sheet of eight strands that is sandwiched with two 3-stranded beta-sheets. Enzymes displaying this motif include domain IIa of the glucose-specific permease from bacteria (EC:2.7.1.69) (IPR001127), which is part of the phosphoenolpyruvate:sugar phosphotransfer system (PTS), a bacterial and mycoplasma system responsible for the uptake of some sugars and their concomitant phosphorylation [PMID: 9705652].

This structural motif is also found in peptidoglycan hydrolase LytM, a member of peptidase family M23, although it contains an extra N-terminal, non-conserved beta-sheet subdomain.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
SUPERFAMILY