Homologous Superfamily

Single hybrid motif (IPR011053)

Short name: Single_hybrid_motif

Overlapping entries


The single hybrid motif has a beta-barrel sandwich hybrid fold, consisting of a sandwich of half-barrel shaped beta-sheets. This motif is found in biotinyl/lipoyl-carrier proteins and domains, where the biotin and lipoic acid moieties act as covalently attached coenzyme cofactors in enzymes that catalyse metabolic reactions. For example, this motif can be found in the biotinyl domain of Escherichia coli acetyl-CoA carboxylase [PMID: 8747466], protein H of the glycine cleavage system in Pisum sativum (Garden pea) [PMID: 10806386], the ipoyl domain of dihydrolipoamide acetyltransferase, which is a component of the pyruvate dehydrogenase complex [PMID: 10913250], the lipoyl domain of the 2-oxoglutarate dehydrogenase complex [PMID: 8950276], and the lipoyl domain f the mitochondrial branched-chain alpha-ketoacid dehydrogenase.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.