Homologous Superfamily

Six-bladed beta-propeller, TolB-like (IPR011042)

Short name: 6-blade_b-propeller_TolB-like

Overlapping entries


This superfamily represents a six-bladed beta-propeller domain consisting of six 4-stranded beta-sheet motifs. This domain can be found in TolB proteins (C-terminal), in soluble quinoprotein glucose dehydrogenase, in calcium-dependent phosphotriesterases, in the low density lipoprotein (LDL) receptor YWTD domain, in nidogen, and in serine/threonine-protein kinase (PknD) NHL repeat domain.

TolB is a periplasmic protein from Escherichia coli that is part of the Tol-dependent translocation system involving group A and E colicins that is used to penetrate and kill cells [PMID: 10545334, PMID: 10673426]. TolB has two domains, an alpha-helical N-terminal domain that shares structural similarity with the C-terminal domain of transfer RNA ligases, and a beta-propeller C-terminal domain that shares structural similarity with numerous members of the prolyl oligopeptidase family and, to a lesser extent, to class B metallo-beta-lactamases (although its does not necessarily occur at the C-terminal in these proteins) [PMID: 10545334]. The C-terminal domain of TolB may mediate protein-protein interactions with colicins.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.