Transcription Factor IIF, Rap30/Rap74, interaction (IPR011039)

Short name: TFIIF_interaction

Domain relationships



Transcription factor IIF (TFIIF), which is essential for eukaryotic transcription by RNA polymerase II. (PolII), consists of a heterodimer of Rap30 (beta) (IPR003196) and Rap74 (alpha) (IPR008851) subunits [PMID: 11183778]. Rap30 and Rap74 have multiple domains that bind to PolII, TFIIB, TAF250 and DNA in interactions that are essential for transcription initiation and elongation. The N-terminal interactions domains of Rap30 and Rap74 are responsible for establishing the dimer interface between the two subunits, this interface being important for TFIIF function [PMID: 12354769].

GO terms

Biological Process

GO:0006367 transcription initiation from RNA polymerase II promoter

Molecular Function

GO:0003824 catalytic activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.