Nop2p (IPR011023)

Short name: Nop2p

Domain relationships


This domain is found in archaeal, bacterial and eukaryotic proteins.

In the archaea and bacteria, they are primarily restricted to the euryarchaeota and proteobacteria respectively; where they are either described as either nucleolar protein or tRNA/rRNA cytosine-C5-methylase. They all have the S-adenosyl methionine (SAM) binding domain and are related to bacterial Fmu (16S rRNA m5C 967 methyltransferase) where the structure of the methyl transferase domain has been determined [PMID: 14656444].

In the eukaryota, the majority are annotated as being 'nucleolar protein'. None of the eukaryotic members in this family have a the SAM binding signature. Despite this, the yeast Nop2p is a probable RNA m(5)C methyltransferase, essential for processing and maturation of 27S pre-rRNA and large ribosomal subunit biogenesis [PMID: 12872006]; localised to the nucleolus and is essential for viability [PMID: 7806561]. Reduced Nop2p expression limits yeast growth and decreases levels of mature 60S ribosomal subunits while altering rRNA processing [PMID: 8972218]. There is substantial identity between Nop2p and human p120 (NOL1), which is also called the proliferation-associated nucleolar antigen [PMID: 7806561, PMID: 2576976].

GO terms

Biological Process

GO:0006364 rRNA processing

Molecular Function

GO:0003723 RNA binding
GO:0008757 S-adenosylmethionine-dependent methyltransferase activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.