Domain

KIND (IPR011019)

Short name: KIND

Domain relationships

None.

Description

The KIND (kinase non-catalytic C-lobe domain) is a putative protein interaction domain, which has been identified as being similar to the C-terminal protein kinase catalytic fold (C lobe) (see PDOC00100).

The presence of the KIND domain at the N terminus of signalling proteins and the absence of the active site residues in the catalytic and activation loops suggest that it folds independently and is likely to be non-catalytic. The occurrence of the domain only in metazoa implies that it has evolved from the catalytic protein kinase domain into an interaction domain possibly by keeping the substrate-binding features [PMID: 12877999, PMID: 16099729].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
PROSITE profiles
SMART