TRASH domain (IPR011017)

Short name: TRASH_dom

Overlapping homologous superfamilies


Domain relationships



TRASH domain contains a well-conserved cysteine motif that may be involved in metal coordination. TRASH is encoded by multiple prokaryotic genomes and is present in transcriptional regulators, cation-transporting ATPases and hydrogenases, and is also present as a stand-alone module. The observed domain associations and conserved genome context of TRASH-encoding genes in prokaryotic genomes suggest that TRASH constitutes a novel component in metal trafficking and heavy-metal resistance. The precise role of the multiple copies of TRASH that are present in vertebrate proteins remains to be elucidated [PMID: 12713899].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.