Homologous Superfamily

Dimeric alpha-beta barrel (IPR011008)

Short name: Dimeric_a/b-barrel

Overlapping entries


Dimeric alpha-beta barrel domains exhibit an alpha+beta sandwich fold with an antiparallel beta sheet that forms a closed barrel. These domains dimerise through the beta-sheet, and in some cases these dimers may assemble into higher oligomers. Domains with this structure are found in proteins from several different families, including bacterial actinorhodin biosynthesis monooxygenase (ActVa-Orf6), which catalyses the oxidation of an aromatic intermediate of the actinorhodin biosynthetic pathway [PMID: 12514126]; bacterial muconalactone isomerase, a decamer composed of five dimers [PMID: 2926818]; and the C-terminal domain of archaeal LprA, a member of the Lrp/AqsnC family of transcription regulators [PMID: 11230123].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.