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Dimeric alpha-beta barrel (IPR011008)
Short name: Dimeric_a/b-barrel
Overlapping entries
- Muconolactone delta-isomerase (IPR003464)
- YCII-related (IPR005545)
- Deferrochelatase/peroxidase EfeB (IPR006313)
- Dyp-type peroxidase (IPR006314)
- Polyketide synthesis cyclase (IPR006765)
- Antibiotic biosynthesis monooxygenase domain (IPR007138)
- Rhamnose/fucose mutarotase (IPR008000)
- EthD domain (IPR009799)
- Protein of unknown function DUF1428 (IPR009874)
- Putative heme-dependent peroxidase/Chlorite dismutase (IPR010644)
- Domain of unknown function DUF1330 (IPR010753)
- Sulphur oxygenase reductase (IPR011661)
- NIPSNAP (IPR012577)
- Stress responsive alpha-beta barrel (IPR013097)
- L-rhamnose mutarotase (IPR013448)
- Putative monooxygenase YdhR (IPR014910)
- 4-Methylmuconolactone methyl-isomerase (IPR018566)
- Transcription regulator AsnC/Lrp, ligand binding domain (IPR019887)
- Transcription regulator AsnC-type (IPR019888)
- Domain of unknown function DUF3291 (IPR021708)
- Conserved hypothetical protein CHP03792 (IPR022512)
- Heme oxygenase IsdG (IPR023953)
- Muconolactone isomerase domain (IPR026029)
- Putative heme-dependent peroxidase, UPF0447 family (IPR031332)
- Domain of unknown function DUF4937 (IPR032555)
- (4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase (IPR033672)
- Polyketide synthesis cyclase superfamily (IPR038474)
Description
Dimeric alpha-beta barrel domains exhibit an alpha+beta sandwich fold with an antiparallel beta sheet that forms a closed barrel. These domains dimerise through the beta-sheet, and in some cases these dimers may assemble into higher oligomers. Domains with this structure are found in proteins from several different families, including bacterial actinorhodin biosynthesis monooxygenase (ActVa-Orf6), which catalyses the oxidation of an aromatic intermediate of the actinorhodin biosynthetic pathway [PMID: 12514126]; bacterial muconalactone isomerase, a decamer composed of five dimers [PMID: 2926818]; and the C-terminal domain of archaeal LprA, a member of the Lrp/AqsnC family of transcription regulators [PMID: 11230123].
Contributing signatures
- SSF54909 (SSF54909)
