Homologous Superfamily

Integration host factor (IHF)-like DNA-binding domain superfamily (IPR010992)

Short name: IHF-like_DNA-bd_dom_sf

Overlapping entries


Integration host factor (IHF) (IPR005684, IPR005685) is a small heterodimeric protein that binds the minor groove of DNA in a sequence-specific manner and induces a large bend. This bending stabilises distinct DNA conformations that are required during several bacterial processes, such as recombination, transposition, replication and transcription [PMID: 12842466]. The core structure of IHF consists of a partly opened 4-helical bundle that is capped with a beta-sheet.

Prokaryotic protein HU and the bacteriophage SPO1 transcription factor TF1 are closely related to IHF. These proteins are collectively referred to as type II DNA-binding proteins (DBPII), forming a group of basic, dimeric proteins found in all bacteria that are able to bind DNA to induce and stabilise DNA bending. HU plays a structural role in replication initiation, transcription regulation, site-specific recombination, and the compaction of the bacterial genome [PMID: 12853489]. TF1 is essential for viral multiplication [PMID: 10993726].

The DNA-binding domain of the TraM protein (IPR007925), an essential component of the DNA transfer machinery of the conjugative resistance plasmid R1, appears to have a similar structure to DBPII [PMID: 11258958].

GO terms

Biological Process

No terms assigned in this category.

Molecular Function

GO:0003677 DNA binding

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.