Ubiquinone biosynthesis hydroxylase UbiH/COQ6 (IPR010971)

Short name: UbiH/COQ6

Overlapping homologous superfamilies


Family relationships


This entry represents a family of FAD-dependent hydroxylases (monooxygenases), which are all believed to act in the aerobic ubiquinone biosynthesis pathway [PMID: 11583838]. In Escherichia coli, three enzyme activities have been described: UbiI, UbiH and UbiF [PMID: 23709220]. UbiH and UbiF are similar to one another and form the basis of this subfamily. UbiI (also known as visC) [PMID: 23709220] is highly similar to UbiF, adjacent to UbiH and, when mutated, results in a phenotype similar to that of UbiH (also known as visB) [PMID: 1339425]. Several other species appear to have three homologues in this family, although they assort themselves differently on phylogenetic trees (e.g. Xylella and Mesorhizobium) making it difficult to ascribe a specific activity to each one. Eukaryotes appear to have only a single homologue in this subfamily (COQ6, [PMID: 12721307]) which complements UbiH, but also possess a non-orthologous gene, COQ7 which complements UbiF.

GO terms

Biological Process

GO:0055114 oxidation-reduction process
GO:0006744 ubiquinone biosynthetic process

Molecular Function

GO:0050660 flavin adenine dinucleotide binding
GO:0016709 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.