Malate dehydrogenase, type 2 (IPR010945)

Short name: Malate_DH_type2

Overlapping homologous superfamilies

Family relationships


Malate dehydrogenases catalyse the interconversion of malate and oxaloacetate using dinucleotide cofactors [PMID: 7849603]. The enzymes in this entry are found in archaea, bacteria and eukaryotes and fall into two distinct groups. The first group are cytoplasmic, NAD-dependent enzymes which participate in the citric acid cycle (EC: The second group are found in plant chloroplasts, use NADP as cofactor, and participate in the C4 cycle (EC:

Structural studies indicate that these enzymes are homodimers with very similar overall topology, though the chloroplast enzymes also have N- and C-terminal extensions, and all contain the classical Rossman fold for NAD(P)H binding [PMID: 8471603, PMID: 10206992, PMID: 10194350, PMID: 10196131]. Substrate specificity is determined by a mobile loop at the active site which uses charge balancing to discriminate between the correct substrates (malate and oxaloacetate) and other potential oxo/hydroxyacid substrates the enzyme may encounter within the cell [PMID: 10075524].

GO terms

Biological Process

GO:0006108 malate metabolic process
GO:0055114 oxidation-reduction process

Molecular Function

GO:0016615 malate dehydrogenase activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.