Class I myosin tail homology domain (IPR010926)

Short name: Myosin_TH1

Overlapping homologous superfamilies


Domain relationships



Class I myosins (Myo1s) are widely expressed in eukaryotic cells. Myo1s exist as monomers and can sense cellular mechanical forces and function as tension- sensitive anchors or transporters. Each Myo1 contains from N terminus to C terminus, a motor domain, a neck region consisting of several calmodulin (CaM)-binding IQ motifs and a tail region. All Myo1s contain a tail homology (TH1) domain featuring an embedded pleckstrin-homology (PH) domain capable of binding to lipid membranes. In addition, Myo1s with long tails also contain a TH2 (or GPA) domain and a C-terminal TH3 (or SH3) domain, the latter of which may be responsible for binding to cargos. All Myo1s are capable of bridging actin cytoskeletons with lipid membranes by using their motor heads and tail TH1 domains.

The TH1 domain is an extended PH domain capable of binding to lipids [PMID: 25437912, PMID: 20071333].

GO terms

Biological Process

No terms assigned in this category.

Molecular Function

GO:0003774 motor activity

Cellular Component

GO:0016459 myosin complex

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
PROSITE profiles