Domain

EngC GTPase (IPR010914)

Short name: EngC_GTPase

Domain relationships

None.

Description

GTPases function as crucial molecular switches in a broad variety of biochemical processes. The majority of GTPases form a vast class of evolutionarily related proteins within the broader class of P-loop-containing ATPases. The P-loop GTPases share a conserved amino acid sequence G1-G3-G4 motif pattern (G2 is less well conserved) present in the GTPase domain. The Escherichia coli protein EngC represents a protein family whose members are broadly conserved in bacteria and are indispensable for growth. The GTPase domain of EngC is very similar to several P-loop GTPases, but differs in having a circular permutation of the GTPase structure described by a G4-G1-G3 pattern [PMID: 12220175]. The EngC-type GTPase domain is predominantly bacterial, with a probable acquisition by plants from chloroplasts [PMID: 11916378].

GO terms

Biological Process

No terms assigned in this category.

Molecular Function

GO:0005525 GTP binding
GO:0003924 GTPase activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
PROSITE profiles