Nitrate/nitrite sensing protein, bacterial (IPR010910)

Short name: Nitrate/nitrite_sensing_bac

Overlapping homologous superfamilies


Domain relationships


The nitrate and nitrite-sensing (NIT) domain is a (~250 aa) sensor domain found in various receptor components of signal transduction pathways from different bacterial lineages [PMID: 12633990]. Proteins containing a NIT domain belong to one of four known classes of prokaryotic signal transduction proteins: intracellular transcription anti-termination regulators, sensor histidine kinases, methyl-accepting chemotaxis proteins, diguanylate cyclases/phosphodiesterases. NIT-containing receptors regulate cellular functions such as gene expression (transcription anti-terminators and histidine kinases), cell motility (chemotaxis receptors), and enzyme activity (diguanylate cyclases/phosphodiesterases), in response to changes in nitrate and/or nitrite concentrations. The NIT domain is found as both an extracellular and an intracellular sensor. The NIT domain can be found in combination with other signalling domains, such as ANTAR, HAMP (IPR003660), MCP, Hemerythrins (IPR002063), CHASE (IPR006189), GGDEF (IPR000160), PAS (IPR000014), EAL (IPR001633), HK (IPR005467), GAF, REC and Hpt (IPR008207).

This entry represents a subgroup found exclusively in bacteria.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
PROSITE profiles