Domain

Calcium-mediated lectin (IPR010907)

Short name: Ca-mediated_lectin

Overlapping homologous superfamilies

Domain relationships

None.

Description

This entry represents calcium-mediated lectins. Structures have been determined for both fucose-binding lectin II (PA-IIL) [PMID: 12909014] and mannose-specific lectin II (RS-IIL) [PMID: 15101976]. These proteins have homologous structures, their monomers consisting of a 9-stranded beta sandwich with Greek-key topology. Each monomer contains two calcium ions that mediate an exceptionally high binding affinity to the monosaccharide ligand in a recognition mode unique among carbohydrate-protein interactions. In Pseudomonas aeruginosa, PA-IIL contributes to the pathogenic virulence of the bacterium, functioning as a tetramer when binding fucose [PMID: 12415289]. In the plant pathogen Ralstonia solanacearum (Pseudomonas solanacearum), RS-IIL recognises fucose, but displays much higher affinity to mannose and fructose, which is opposite to the preference of PA-IIL.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
Pfam