Family

Tumor suppressor ARF (IPR010868)

Short name: Tumor_suppres_ARF

Family relationships

None.

Description

ARF (also known as p14ARF in the human and p19ARF in the mouse) is an alternative transcript of the INK4a/ARF tumour-suppressor locus that encodes p16INK4a, an inhibitor of cyclin dependent kinases. ARFs are tumour suppressors participating in p53-dependent or independent pathways that restrain abnormal cell growth and maintain genomic stability [PMID: 25723571, PMID: 16600663,PMID: 12660818]. ARF interacts with MDM2 and neutralizes MDM2's inhibition of p53 [PMID: 11331246]. Mdm2 may also regulate ARF turnover by mediating its degradation through the proteasome [PMID: 25723571]. p14ARF has also been shown to interact with E2F factors to form p14ARF-E2F/partner-DNA complexes repressing E2F-dependent transcription [PMID: 20082327].

GO terms

Biological Process

GO:0006915 apoptotic process
GO:0007050 cell cycle arrest
GO:0008285 negative regulation of cell proliferation

Molecular Function

No terms assigned in this category.

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
Pfam