ProSAAS (IPR010832)

Short name: ProSAAS

Overlapping homologous superfamilies


Family relationships



Prohormone convertases (PCs) 1 and 2 are a family of eukaryotic subtilisins thought to mediate the proteolytic cleavage of many peptide precursors [PMID: 10409610].

This family represents proSAAS, which belongs to MEROPS inhibitor family I49. It is a neuroendocrine secretory protein which is a potent endogenous PC1 inhibitor [PMID: 10632593, PMID: 11742530]. ProSAAS consists of an N-terminal domain and a C-terminal domain separated by a furin cleavage site. The inhibitory region of proSAAS is located in the C-terminal domain and includes the LLRVKR hexapeptide sequence [PMID: 10816562, PMID: 11719503, PMID: 15283695]. Furthermore, ProSAAS has been shown to function as an amyloid anti-aggregant chaperon in Alzheimer's disease [PMID: 24102330]. ProSAAS-derived peptides are involved in several physiologically important processes [PMID: 22164236, PMID: 20367757, PMID: 20830308].

GO terms

Biological Process

GO:0010951 negative regulation of endopeptidase activity

Molecular Function

GO:0004866 endopeptidase inhibitor activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.