POTRA domain, BamA/TamA-like (IPR010827)

Short name: BamA/TamA_POTRA

Overlapping homologous superfamilies


Domain relationships

  • POTRA domain (IPR034746)
    • POTRA domain, BamA/TamA-like (IPR010827)


In Gram-negative bacteria, beta-barrel proteins are integrated into the outer membrane by the beta-barrel assembly machinery, with key components of the machinery being the Omp85 family members BamA and TamA [PMID: 25976323]. The BamA periplasmic domain is composed of five globular subdomains in tandem called POTRA motifs. They are key to BAM complex formation and interaction with the substrate beta-barrel proteins [PMID: 27332128]. TamA has three periplasmic POTRA domains [PMID: 26427691, PMID: 26243377, PMID: 24056943]. Outer mebrane proteins with a variable number of POTRA motifs are also found in mitochondria and chloroplasts [PMID: 24411168].

GO terms

Biological Process

No terms assigned in this category.

Molecular Function

No terms assigned in this category.

Cellular Component

GO:0019867 outer membrane

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.