B9 domain (IPR010796)

Short name: B9_dom

Overlapping homologous superfamilies


Family relationships



B9 domain containing proteins are found in flagellar or cilia-containing species. Although its function is unknown, a cilia-specific role has been suggested for the poorly characterised B9 domain [PMID: 16415886, PMID: 17127412, PMID: 18337471]. Some proteins known to contain a B9 domain are listed below:

  • Mammalian Meckel syndrome 1 (MKS1) protein, which may be related to the ciliary basal body.
  • Mammalian protein B9D1 and B9D2.
  • Caenorhabditis elegans X-box promoter element regulated protein 7 (xbx-7). It corresponds to mammalian MKS1.
  • Caenorhabditis elegans ciliary transition zone associate protein 1 (tza-1). It corresponds to mammalian B9D2.
  • Caenorhabditis elegans ciliary transition zone associate protein 2 (tza-2). It corresponds to mammalian B9D1.
  • Paramecium tetraurelia ICIS-1 (Involved in Cilia Stability-1), the B9D2 homolog.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
PROSITE profiles