Domain

Homologous-pairing protein 2, winged helix domain (IPR010776)

Short name: Hop2_WH_dom

Overlapping homologous superfamilies

Domain relationships

None.

Description

Homologous-pairing protein 2 (Hop2) is required for proper homologous pairing and efficient cross-over and intragenic recombination during meiosis [PMID: 9708739, PMID: 11447128, PMID: 15192114].

The mammalian HOP2 homologue, TBPIP, was first identified as a factor interacting with TBP-1, which binds to the human immunodeficiency virus, type 1 Tat protein [PMID: 9345291]. Later, TBPIP was found to be an activator that specifically stimulates the homologous pairing catalyzed by DMC1 [PMID: 15192114].

This entry represents the winged helix domain found in Hop2.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
Pfam