Homologous-pairing protein 2 (IPR010776)

Short name: Hop2

Overlapping homologous superfamilies


Family relationships



This entry includes yeast homologous-pairing protein 2 (Hop2) and its homologues from animals and plants. They are required for proper homologous pairing and efficient cross-over and intragenic recombination during meiosis [PMID: 9708739, PMID: 11447128, PMID: 15192114].

The mammalian HOP2 homologue, TBPIP, was first identified as a factor interacting with TBP-1, which binds to the human immunodeficiency virus, type 1 Tat protein [PMID: 9345291]. Later, TBPIP was found to be an activator that specifically stimulates the homologous pairing catalyzed by DMC1 [PMID: 15192114].

GO terms

Biological Process

GO:0007131 reciprocal meiotic recombination

Molecular Function

No terms assigned in this category.

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.