Domain

RecQ helicase-like 5 (IPR010716)

Short name: RECQ5

Domain relationships

None.

Description

This entry represents a domain found in RECQ5. RecQ helicases is a group of highly conserved 3'-5' DNA helicases involved in maintaining genomic stability. RECQ5 plays an important role in DNA replication, transcription and repair [PMID: 20643585, PMID: 20348101]. It interacts with RNA polymerase II to reduce transcription-associated replication impairment and recombination [PMID: 20231364]. As a helicase, it can disrupt RAD51 filaments assembled on ssDNA, thereby inhibiting homologous recombination [PMID: 23748380]. It also participates in psoralen-induced interstrand cross-link repair [PMID: 23715498]. It stimulates DNA decatenation mediated by TOP2A [PMID: 22013166].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
Pfam
ProDom