Dedicator of cytokinesis, C-terminal (IPR010703)

Short name: DOCK_C

Overlapping homologous superfamilies


Domain relationships



This entry represents a conserved region of approximately 200 residues within a number of eukaryotic dedicator of cytokinesis (DOCK) proteins. These proteins are potential guanine nucleotide exchange factors that activate some small GTPases, such as Rac, by exchanging bound GDP for free GTP [PMID: 12432077]. DOCK proteins are required during several cellular processes, such as cell motility and phagocytosis. For instance, DOCK2 is specifically expressed in haemopoietic cells, and plays a critical role in lymphocyte migration [PMID: 12829596]. This region interacts with RAC1 and ELMO1 [PMID: 22331897].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.