Family

Plethodontid receptivity factor PRF/cardiotrophin-like (IPR010681)

Short name: PRF/CT

Family relationships

None.

Description

This family includes plethodontid receptivity factor (PRF) proteins which seem to be specific to Plethodon jordani (Jordan's salamander). PRF is a courtship pheromone produced by males increase female receptivity [PMID: 10489368].

This family also includes cardiotrophin-2 (neuropoietin) and cardiotrophin-like cytokine factor 1 (CLCF1) from mammals, which share sequence similarity to PRF [PMID: 15014164]. They are four-helix bundle cytokines that signal through the gp130 receptor subunit [PMID: 26198769].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
PANTHER
Pfam