Reverse transcriptase thumb (IPR010661)

Short name: RVT_thumb

Overlapping homologous superfamilies


Domain relationships



This domain is known as the thumb domain. It is composed of a four helix bundle [PMID: 1377403]. Reverse transcriptase converts the viral RNA genome into double-stranded viral DNA. Reverse transcriptase often occurs in a polyprotein; with integrase, ribonuclease H and/or protease, which is cleaved before the enzyme takes action. The impact of antiretroviral treatment on the first 400 amino acids of HIV reverse transcriptase is good. Little is known, however, of the antiretroviral drug impact on the C-terminal domains of Pol, which includes the thumb, connection and RNase H [PMID: 18335052]. Evidence suggests that these might be well conserved domains.

GO terms

Biological Process

GO:0006278 RNA-dependent DNA biosynthetic process

Molecular Function

GO:0003964 RNA-directed DNA polymerase activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.