Domain

Pre-mRNA cleavage complex II Clp1 (IPR010655)

Short name: Pre-mRNA_cleavage_cplxII_Clp1

Domain relationships

None.

Description

This entry consists of several pre-mRNA cleavage complex II Clp1 (or HeaB) proteins. Six different protein factors are required in vitro for 3' end formation of mammalian pre-mRNAs by endonucleolytic cleavage and polyadenylation. Clp1 is involved in both the endonucleolyitc cleavage and polyadenylation steps of mRNA 3'-end maturation [PMID: 11344258].

This entry also includes nucleolar proteins [PMID: 15112237].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
Pfam