Domain

Pre-mRNA cleavage complex subunit Clp1 (IPR010655)

Short name: Pre-mRNA_cleavage_Clp1

Domain relationships

None.

Description

The yeast Clp1 is a subunit of cleavage factor IA (CF IA) and is involved in mRNA cleavage and polyadenylation [PMID: 22216186]. Clp1 also mediates interactions between CF IA and another complex of the yeast mRNA cleavage and polyadenylation machinery, the Cleavage-Polyadenylation Factor (CPF) [PMID: 21993299]. It seems that human Clp1 and yeast Clp1 are not functional orthologues [PMID: 18648070]. Human Clp1, and its archeal homologue [PMID: 19299550], but not yeast Clp1, are 5'-OH polynucleotide kinases. In humans Clp1 functions as a RNA kinase important in tRNA splicing [PMID: 18648070, PMID: 24766809], and is also implicated in mRNA and siRNA maturation [PMID: 15109492, PMID: 17495927, PMID: 17786051].

GO terms

Biological Process

GO:0031124 mRNA 3'-end processing

Molecular Function

No terms assigned in this category.

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
Pfam