Mib-herc2 (IPR010606)

Short name: Mib_Herc2

Overlapping homologous superfamilies

Domain relationships



Mib is a RING ubiquitin ligase in the Notch pathway. Mib interacts with the intracellular domain of Delta to promote its ubiquitylation and internalisation. Cell transplantation studies suggest that mib function is essential in the signalling cell for efficient activation of Notch in neighbouring cells. This domain has been named 'mib/herc2 domain' in [PMID: 12530964] and usually the protein also contains an E3 ligase domain (either Ring or Hect).

GO terms

Biological Process

GO:0016567 protein ubiquitination

Molecular Function

GO:0046872 metal ion binding
GO:0004842 ubiquitin-protein transferase activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
PROSITE profiles