Methuselah, N-terminal domain (IPR010596)

Short name: Methuselah_N_dom

Overlapping homologous superfamilies

Domain relationships



Drosophila Methuselah (Mth) mutants have a 35% increase in average lifespan and increased resistance to several forms of stress, including heat, starvation, and oxidative damage. The protein affected by this mutation is related to G protein-coupled receptors of the secretin receptor family. Mth, like secretin receptor family members, has a large N-terminal ectodomain, which may constitute the ligand binding site [PMID: 11274391].

This entry represents the N-terminal domain of the Methuselah protein.

GO terms

Biological Process

GO:0006950 response to stress

Molecular Function

GO:0004930 G-protein coupled receptor activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.