Domain

Catalase immune-responsive domain (IPR010582)

Short name: Catalase_immune_responsive

Domain relationships

None.

Description

Catalases (EC:1.11.1.6) are antioxidant enzymes that catalyse the conversion of hydrogen peroxide to water and molecular oxygen, serving to protect cells from its toxic effects [PMID: 11351128]. Hydrogen peroxide is produced as a consequence of oxidative cellular metabolism and can be converted to the highly reactive hydroxyl radical via transition metals, this radical being able to damage a wide variety of molecules within a cell, leading to oxidative stress and cell death. Catalases act to neutralise hydrogen peroxide toxicity, and are produced by all aerobic organisms ranging from bacteria to man. Most catalases are mono-functional, haem-containing enzymes, although there are also bifunctional haem-containing peroxidase/catalases (IPR000763) that are closely related to plant peroxidases, and non-haem, manganese-containing catalases (IPR007760) that are found in bacteria [PMID: 14745498].

This entry represents a small conserved region within catalase enzymes that carries the immune-responsive amphipathic octa-peptide that is recognised by T cells [PMID: 15585332].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
Pfam