Protein LIN-9/Protein ALWAYS EARLY (IPR010561)
Short name: LIN-9/ALY1
Overlapping homologous superfamilies
- Protein LIN-9/Protein ALWAYS EARLY (IPR010561)
- Protein ALWAYS EARLY, plant (IPR028306)
This entry represents protein LIN-9/ALWAYS EARLY (LIN-9/ALY). LIN-9 from Caenorhabditis elegans is a homologue of the Drosophila always early (ALY) protein, which functions as a repressor of cell cycle regulated genes [PMID: 23667535, PMID: 15246533].
LIN-9 is a component of the evolutionary conserved DREAM (MuvB/DRM) complex, which represses transcription [PMID: 17075059]. DREAM complex undergoes a cell cycle dependent switch of subunits. DREAM core binds to the E2F4 transcription factor and to the RBL2 (p130) in quiescent cells, while associates with the transcription factor B-MYB in the S-phase [PMID: 23667535]. In humans, LIN-9 acts as a tumor suppressor and plays a role in the expression of genes required for the G1/S transition [PMID: 15538385, PMID: 16730350]. In pluripotent embryonic stem cells (ESC), LIN-9 plays an important role for proliferation and genome stability by activating genes with important functions in mitosis and cytokinesis [PMID: 23667535].
In Arabidopsis thaliana, ALY is expressed ubiquitously in vegetative and reproductive tissues [PMID: 1524653].
- PTHR21689 (PTHR21689)