BNIP3 (IPR010548)

Short name: BNIP3

Overlapping homologous superfamilies


Family relationships



This family consists of several mammalian specific BCL2/adenovirus E1B 19 kDa protein-interacting protein 3 or BNIP3 sequences. BNIP3 belongs to the Bcl-2 homology 3 (BH3)-only family, a Bcl-2-related family possessing an atypical Bcl-2 homology 3 (BH3) domain, which regulates PCD from mitochondrial sites by selective Bcl-2/Bcl-XL interactions. BNIP3 family members contain a C-terminal transmembrane domain that is required for their mitochondrial localisation, homodimerisation, as well as regulation of their pro-apoptotic activities. BNIP3-mediated apoptosis has been reported to be independent of caspase activation and cytochrome c release and is characterised by early plasma membrane and mitochondrial damage, prior to the appearance of chromatin condensation or DNA fragmentation [PMID: 12690108].

GO terms

Biological Process

GO:0043065 positive regulation of apoptotic process

Molecular Function

No terms assigned in this category.

Cellular Component

GO:0016021 integral component of membrane
GO:0005740 mitochondrial envelope

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.